KELAPROFEN

Description

Solution for injections

Composition

1 ml of the drug contains the active substance: ketoprofen — 100 mg. The other ingredients are benzyl alcohol, L-arginine, citric acid anhydrous, water for injections.

Indications for use

• Cattle: anti-inflammatory, analgesic and antipyretic medicinal product for the treatment of inflammatory processes caused by respiratory diseases, breast oedema, acute mastitis, inflammatory processes in the musculoskeletal system. Horses: treatment of inflammatory and painful conditions in musculoskeletal disorders, in particular: lameness of traumatic origin, arthritis, arthrosis, joint injuries (tight ligaments, synovitis), fractures, tendinitis. Symptomatic treatment of colic.
• Pigs: anti-inflammatory, analgesic and antipyretic therapy for metritis-mastitis-agalactia syndrome, treatment of inflammatory and pain conditions for diseases of the musculoskeletal system; with respiratory infections.

Pharmacological properties

ATC vet classification code: QMO1A Nonsteroidal anti-inflammatory and anti-rheumatic veterinary drugs. QMO1AE03 Ketoprofen. Ketoprofen — is a nonsteroidal anti-inflammatory drug of the group of carboxylic acids, derivatives of propionic acid, which has analgesic and antipyretic properties. The mechanism of action of the drug, like other representatives of the group of nonsteroidal anti-inflammatory drugs, consists in inhibiting the enzyme cyclooxygenase, which ensures the transformation of arachidonic acid into prostaglandins. Ketoprofen inhibits the activity of bradykinin, which excites pain nerve endings and thereby provokes pain and contributes to the stabilization of lysosomal membranes, which prevents the release of lysosomal enzymes and prevents tissue destruction. When the medicinal product is administered intramuscularly, the maximum plasma concentration of ketoprofen is noted after 30 minutes. The bioavailability of ketoprofen varies from 80% to 100% depending on the animal species. Ketoprofen is excreted from the body mainly through the kidneys.

Dosage

• Cattle: intravenous or intramuscular 3 mg ketoprofen/kg body weight (equivalent to 1 ml Kelaprofen /33 kg body weight) once daily for 3 days. Horses: intravenous. For the treatment of bone and joint lesions and musculoskeletal disorders: 2.2 mg ketoprofen/kg body weight (equivalent to 1 ml Kelaprofen /45 kg body weight) once daily for 3 to 5 days. For symptomatic treatment of colic: 2.2 mg ketoprofen/kg body weight (equivalent to 1 ml Kelaprofen/45 kg body weight) once. Additional injections of — only after repeated clinical examination of the animal by a veterinary physician.
• Pigs: Intramuscular 3 mg ketoprofen/kg body weight (equivalent to 1 ml Kelaprofen /33 kg body weight) once daily.

Withdrawal period

Slaughter of animals for meat is allowed: cattle when administered intravenously — after 1 day; cattle, pigs when administered intramuscularly — 4 days after the last administration. By the specified time limit, the meat is fed to unproductive animals or disposed of (depending on the opinion of the veterinary medicine doctor). There is no withdrawal period for milk!

Contraindications

Do not use in animals with increased sensitivity to the components of the drug. Do not use in animals with gastric or duodenal ulcers, haemorrhagic syndrome, severe renal or hepatic impairment. Do not use simultaneously with other NSAIDs, glucocorticoids, anticoagulants and diuretics. Do not use in foals younger than 15 days. Do not use in colt mares. Do not use in productive horses whose meat is intended for human consumption. Do not use intraarterially.

Side effect

There is a possibility of a negative effect on the mucous membrane of the stomach. Intramuscular injections sometimes cause a fleeting sensation of irritation. Allergic reactions can occur very rarely.

Interaction with other means and other forms of interaction

Do not use simultaneously with other NSAIDs, glucocorticoids, anticoagulants and diuretics.

Special precautions for use

Use in animals less than 6 weeks of age or in old animals may lead to additional risk. If such use cannot be avoided, the dose should be reduced and the animals carefully cared for. Use in dehydrated animals, hypovolaemic animals or low pressure animals should be avoided as there is a potential risk of increased renal toxicity. Do not mix with other drugs in the same syringe.

Shelf life

3 years. After the first selection from the bottle — 28 days. Dry, dark place, at a temperature of 5–25°C. Do not freeze.

Packaging

Glass bottles of 100 ml.