DOXIPAN 54

Description

Doxycycline — powder for oral use

•Perfect treatment of respiratory infections.

•Excellent rotation with enrofloxacin.

•High efficiency.

• Light solubility and prolonged activity of dr.

• Drinking the drug in the morning, cover the daily dose.

Composition

1 g of the drug contains the active substance: doxycycline hyclate (doxycycline) — 500 mg.

Pharmacological action

Doxycycline is a bacteriostatic antibiotic belonging to the tetracycline group. It blocks the attachment of aminoacyl tRNA to the acceptor site, which inhibits the attachment of new amino acids to the peptide chain and thus inhibits protein synthesis. The drug has a bacteriostatic effect on gram-positive microorganisms (Staphylococcus spp. and Strep-tococcus spp.) and grams of negative microorganisms (Actino-bacillus spp., Bordetella spp., Brachispira spp., Brucella spp., E. coli, Haemophilus spp., Leptospira spp., Ornithobacterium spp., Pasteurella multoci-da, Salmonella spp.), as well as mycoplasma (Mycoplasma spp.), rickettsia (Rickettsia spp.) and chlamydia (Chlamydia spp.).
After oral administration to animals, doxycycline is absorbed from the digestive tract by 93–100% and is quickly distributed throughout the body. A serum concentration of about 3 mg/ml provides a therapeutic effect. The maximum concentration in the blood is detected after 3 hours, and the therapeutic concentration is maintained for 18–24 hours. Doxycycline is excreted from the body, both in the form of metabolites and in an unchanged state, mainly with bile.

Dosage and method of administration

Broiler chickens and turkeys: treatment of poultry suffering from chronic respiratory diseases caused by O. rhinotracheale, P. multocida, M. synoviae susceptible to doxycycline.
Pigs: treatment of animals suffering from mycoplasmosis, syndrome MMA (mastitis-metritis-agalactia), as well as respiratory diseases caused by microorganisms (A. pleuropneumonia, B. bronchiseptica, P. multocida, M. hyopneumoniae) sensitive to doxycycline.

Used orally:

• broiler chickens — 15–25 g of Doxypan 54 per 100 liters of drinking water, which is equal to 10 mg of doxycycline per 1 kg of body weight. Course of treatment —5 days;
• turkeys — 40 g of Doxypan 54 per 100 l of drinking water, which is equal to 20 mg of doxycycline per 1 kg of body weight. Course of treatment —5 days;
• pigs — 0.2 g of Doxypan 54 for every 10 kg of body weight equal to 10 mg of doxycycline per 1 kg of body weight. The course of treatment is — 5 days. If group therapy is carried out, the daily dose of the drug for animals is calculated according to the formula: (mg of the active substance /kg of body weight x average body weight of animals (kg) x number of animals) /total amount of water (liquid feed) per day (l) = mg of the active substance per 1 liter of drinking water/liquid feed.

Contraindications

Increased individual sensitivity to doxycycline.
Do not use in laying hens and turkeys whose eggs are used for human consumption.
Do not prescribe animaliasis with impaired liver function.
Do not use simultaneously with bactericidal antibiotics such as penicillins and cephalosporins.
Do not use together with antacids, kaolin and substances containing iron, zinc, magnesium, calcium and aluminum.

Reservation

Slaughter of animals and poultry for meat is allowed after 4 days (pigs), 10 days (turkeys) and 3 days (broiler chickens) after the last use of the drug. The resulting meat is disposed of or fed to unproductive animals, depending on the opinion of the veterinary medicine doctor.

Storage

A dry, dark place inaccessible to children at a temperature of 15°С to 25°С.

Shelf life

Shelf life — 2 years.
Storage period after first opening — 3 months (for packaging of 5 kg each).
Shelf life after dilution with drinking water — 6 hours.

Release form

Primary packaging — double paper-polyethylene bags, secondary packaging — bucket of 5 kg.